Once you've saved your file as a PSD, you cannot go back and re-edit that file, but you do still have your original file to start over with.
Given that a) a file saved as a PSD with Photoshop (unflattened) does allow one to re-edit the saved PSD and b) one may have spent a significant time performing Camera Raw Processing of the file, isnt that a very significant downside to Camera Raw Processing, notwithstanding its extensive capabilties for editing an image?