Cheryl,
I tried to duplicate your situation as best I could. Pro CS4, although I'm an absolute newbie with it - strictly Elements to this point. 4000 x 3000 photo wall with 6 1200 x 900 images (2 rows of 3), all of which had a photo frame applied. Scale to frame size is checked. (I used 300ppi rather than 72 ppi). White background and flattened to a single psd file. The clip is 30 seconds long, with scale, zoom, tilt, and swivel. That clip rendered in under 2 minutes. I did have one problem - the image quality is poor and it looks like there are some deinterlacing issues. That may be my inexperience with Pro there, since I haven't really done any training on how best to set it up.
EDIT - Tried it again without scale to frame size. Quality is much, much better, but rendering is painfully slow. I'll keep playing with this as it's something I'd like to know more about.
Let me know if you would like me to adjust any settings or try anything different.
Dick